Healthy Adolescents' Neural Response to Reward: Associations With Puberty, Positive Affect, and Depressive Symptoms
Healthy Adolescents' Neural Response to Reward: Associations With Puberty, Positive Affect, and Depressive Symptoms
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DOI：
10.1016/j.jaac.2009.11.006
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发表时间：
2010-02-01
影响因子：
13.3
通讯作者：
Dahl, Ronald E.
中科院分区：
文献类型：
--
作者：
Forbes, Erika E.;Ryan, Neal D.;Dahl, Ronald E.
目的：奖赏相关行为的改变是正常青少年情感发展的重要组成部分。了解这些规范变化的神经基础为调查青春期是情感障碍、物质使用障碍和健康问题的脆弱时期奠定了基础。对奖赏相关大脑功能的研究发现，关于纹状体和内侧前额叶皮质(MPFC)反应性的发育变化，存在相互矛盾的发现，并且没有考虑青春期。目前的研究重点是青春期特有的大脑功能变化及其与情绪的关联。方法：选取77名健康青少年(青春期前/青春期前期26例，青春期中后期51例)，平均年龄11.94岁(SD=0.75)，进行性成熟和血睾酮测评，完成带奖金的功能性磁共振成像(FMRI)猜想任务，并在自然环境中进行情绪体验采样。作为对比，19名健康成年人完成了功能磁共振成像评估。结果：青春期成熟较早的青少年在奖励结果中表现出较少的纹状体和较多的mPFC反应性。在男孩的奖赏预期中，睾酮与纹状体反应性呈正相关，而在女孩和男孩的奖赏结果中，睾酮与纹状体反应性呈负相关。纹状体反应性与真实世界的主观积极情绪呈正相关，与抑郁症状呈负相关。MPFC反应性与抑郁症状呈正相关。结论：奖赏相关脑功能随着青春期的变化而改变，并与青少年的积极情绪和抑郁症状有关。在这个发育点，更多的寻求奖励的行为可以用来补偿这些变化。J.Am阿卡德。青春期儿童。精神病学，2010；49(2)：162-172。
Objective: Changes in reward-related behavior are an important component of normal adolescent affective development. Understanding the neural underpinnings of these normative changes creates a foundation for investigating adolescence as a period of vulnerability to affective disorders, substance use disorders, and health problems. Studies of reward-related brain function have revealed conflicting findings regarding developmental change in the reactivity of the striatum and medial prefrontal cortex (mPFC) and have not considered puberty. The current study focused on puberty-specific changes in brain function and their association with mood. Method: A sample of 77 healthy adolescents (26 pre-/early pubertal, 51 mid-/late pubertal) recruited in a narrow age range (mean = 11.94 years, SD = 0.75) were assessed for sexual maturation and circulating testosterone, completed a functional magnetic resonance imaging (fMRI) guessing task with monetary reward, and underwent experience sampling of mood in natural environments. For comparison, 19 healthy adults completed the fMRI assessment. Results: Adolescents with more advanced pubertal maturation exhibited less striatal and more mPFC reactivity during reward outcome than similarly aged adolescents with less advanced maturation. Testosterone was positively correlated with striatal reactivity in boys during reward anticipation and negatively correlated with striatal reactivity in girls and boys during reward outcome. Striatal reactivity was positively correlated with real-world subjective positive affect and negatively correlated with depressive symptoms. mPFC reactivity was positively correlated with depressive symptoms. Conclusions: Reward-related brain function changes with puberty and is associated with adolescents' positive affect and depressive symptoms. Increased reward-seeking behavior at this developmental point could serve to compensate for these changes. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(2): 162-172.