Curromycin A as a GRP78 downregulator and a new cyclic dipeptide from Streptomyces sp.
Curromycin A as a GRP78 downregulator and a new cyclic dipeptide from Streptomyces sp.
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Curromycin A 作为 GRP78 下调剂和来自链霉菌属的新型环状二肽。
DOI：
10.1038/ja.2015.115
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Yoichi Hayakawa
中科院分区：
文献类型：
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作者：
伊藤卓;濱野真理子;加藤優;犀川陽子;中田雅也;犀川陽子;Yoichi Hayakawa
由于血液循环不良，实体癌通常营养缺乏，并且这种肿瘤细胞对营养缺乏表现出显著的耐受性。因此，靶向抵抗营养剥夺的抗肿瘤物质可能对实体癌细胞显示出选择性活性。在营养缺乏条件下筛选选择性细胞毒性化合物的过程中，发现放线菌菌株RAI 364产生活性物质。根据16SrRNA序列分析，RAI364菌株与链霉菌属Streptomyces2的16SrRNA序列具有高度的同源性，
Solid cancers are often nutrient-starved because of poor blood circulation and such tumor cells show remarkable tolerance to nutrient deprivation. 1 Thus, antitumor substances targeting resistance to nutrient deprivation may show selective activity against solid cancer cells. In the course of a screening for selective cytotoxic compounds under nutrient-deprived conditions, an actinomycete strain RAI364 was found to produce an active substance. Strain RAI364 was identified as a member of the genus Streptomyces based on the 16S rRNA sequence, 2 which revealed high identity with those of