Exploring the relation of alcohol consumption to risk of breast cancer
Exploring the relation of alcohol consumption to risk of breast cancer
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DOI：
10.1093/aje/154.8.740
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发表时间：
2001-10-15
影响因子：
5
通讯作者：
Rothman, KJ
中科院分区：
文献类型：
--
作者：
Ellison, RC;Zhang, YQ;Rothman, KJ
关于饮酒与女性患乳腺癌风险之间的关系，仍有一些挥之不去的问题。作者对1999年进行的流行病学研究进行了荟萃分析，以检查剂量-反应关系，并评估效应估计值是否因各种研究特征而异。总的来说，乳腺癌的相对风险随着饮酒而单调增加，但影响的幅度很小;与不饮酒者相比，平均每天饮酒12 g（大约一杯典型的饮料）的女性的相对风险为1.10（95%置信区间（CI）：1.06，1.14）。基于医院的病例对照研究中的相对风险估计比队列研究或基于社区的病例对照研究高7%，1990年之前发表的研究比之后发表的研究高3%，在美国以外进行的研究中高5%比美国研究。自1990年以来发表的5项美国队列研究结果显示，与不饮酒者相比，12 g/天的消费者的相对风险为1.06（95% CI：1.00，1.11）。随访时间少于10年的队列研究的估计值比随访时间更长的队列研究高出11%。绝经状态或饮用的饮料类型没有观察到有意义的差异。
There are lingering questions regarding the relation between alcohol consumption and breast cancer risk in women. The authors performed a meta-analysis of epidemiologic studies carried out through 1999 to examine the dose-response relation and to assess whether effect estimates differed according to various study characteristics. Overall, there was a monotonic increase in the relative risk of breast cancer with alcohol consumption, but the magnitude of the effect was small; in comparison with nondrinkers, women averaging 12 g/day of alcohol consumption (approximately one typical drink) had a relative risk of 1.10 (95% confidence interval (Cl): 1.06, 1.14). Estimates of relative risk were 7% greater in hospital-based case-control studies than in cohort studies or community-based case-control studies, 3% greater in studies published before 1990 than in studies published later, and 5% greater in studies conducted outside of the United States than in US studies. The findings of five US cohort studies published since 1990 yielded a relative risk of 1.06 (95% Cl: 1.00, 1.11) for consumers of 12 g/day, as compared with nondrinkers. Cohort studies with less than 10 years of follow-up gave estimates 11% higher than cohort studies with longer follow-up periods. No meaningful difference was seen by menopausal status or type of beverage consumed.