Functional Circuitry of the Retina.
Functional Circuitry of the Retina.
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DOI：
10.1146/annurev-vision-082114-035334
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发表时间：
2015-11-24
影响因子：
6
通讯作者：
Singer JH
中科院分区：
文献类型：
--
作者：
Demb JB;Singer JH
The mammalian retina is an important model system for studying neural circuitry: Its role in sensation is clear, its cell types are relatively well defined, and its responses to natural stimuli—light patterns—can be studied in vitro. To solve the retina, we need to understand how the circuits pre-synaptic to its output neurons, ganglion cells, divide the visual scene into parallel representations to be assembled and interpreted by the brain. This requires identifying the component interneurons and understanding how their intrinsic properties and synapses generate circuit behaviors. Because the cellular composition and fundamental properties of the retina are shared across species, basic mechanisms studied in the genetically modifiable mouse retina apply to primate vision. We propose that the apparent complexity of retinal computation derives from a straightforward mechanism—a dynamic balance of synaptic excitation and inhibition regulated by use-dependent synaptic depression—applied differentially to the parallel pathways that feed ganglion cells.
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DOI：
10.1523/jneurosci.1218-09.2009
发表时间：
2009-07-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Crook JD;Davenport CM;Peterson BB;Packer OS;Detwiler PB;Dacey DM
通讯作者：
Dacey DM
影响因子：
5.3
作者：
Borghuis, Bart G.;Looger, Loren L.;Demb, Jonathan B.
通讯作者：
Demb, Jonathan B.
DOI：
10.1073/pnas.93.2.560
发表时间：
1996-01-23
影响因子：
11.1
作者：
Baylor, D
通讯作者：
Baylor, D
影响因子：
64.8
作者：
Chavez, Andres E.;Singer, Joshua H.;Diamond, Jeffrey S.
通讯作者：
Diamond, Jeffrey S.
影响因子：
5.5
作者：
CLELAND, BG;DUBIN, MW;LEVICK, WR
通讯作者：
LEVICK, WR