The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes
The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes
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DOI：
10.1093/schbul/sbq080
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发表时间：
2010-09-01
影响因子：
6.6
通讯作者：
Corvin, Aiden
中科院分区：
文献类型：
--
作者：
Donohoe, Gary;Morris, Derek W.;Corvin, Aiden
作为第一个对精神病具有全基因组意义的基因，ZNF 804A可以预见地成为了激烈的研究活动的主题。我们回顾了迄今为止精神分裂症与已确定的原始风险变异rs 1344706以及该位点其他常见和罕见变异之间关联的证据。我们描述了仍然缺乏文献的ZNF 804A的生物学功能，并讨论了正在努力表征和完善相关的表型，使用成像和神经心理学的方法。我们的结论是，ZNF 804A是强大的，如果适度，与精神分裂症的风险，还有很多工作要做，以阐明其在精神分裂症生物学的作用。
As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and the original risk variant rs1344706 identified as well as additional common and rare variants at this locus. We describe the still scant literature on the biological function of ZNF804A and discuss the efforts being made to characterize and refine the associated phenotype using imaging and neuropsychological approaches. We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology.