Hepatitis C Viremia and the Risk of Chronic Kidney Disease in HIV-Infected Individuals
Hepatitis C Viremia and the Risk of Chronic Kidney Disease in HIV-Infected Individuals
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DOI：
10.1093/infdis/jit373
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发表时间：
2013-10-15
影响因子：
6.4
通讯作者：
Butt, Adeel A.
中科院分区：
文献类型：
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作者：
Lucas, Gregory M.;Jing, Yuezhou;Butt, Adeel A.
背景活动性丙型肝炎病毒（HCV）复制在慢性肾脏病（CKD）风险中的作用尚未阐明。我们比较了一个大型队列中HCV血清阴性、HCV病毒血症（可检测到HCV RNA）或HCV病毒血症（HCV血清阳性，不可检测到HCV RNA）的HIV感染受试者的CKD发病率。根据标准标准定义3期和5期CKD。进展性CKD定义为肾小球滤过率（GFR）从基线持续降低25%至GFR
Background. The role of active hepatitis C virus (HCV) replication in chronic kidney disease (CKD) risk has not been clarified.Methods. We compared CKD incidence in a large cohort of HIV-infected subjects who were HCV seronegative, HCV viremic (detectable HCV RNA), or HCV aviremic (HCV seropositive, undetectable HCV RNA). Stages 3 and 5 CKD were defined according to standard criteria. Progressive CKD was defined as a sustained 25% glomerular filtration rate (GFR) decrease from baseline to a GFR