Invasion and metastasis in pancreatic cancer.
Invasion and metastasis in pancreatic cancer.
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DOI：
10.1186/1476-4598-2-14
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发表时间：
2003-01-22
期刊：
影响因子：
37.3
通讯作者：
Friess, Helmut
中科院分区：
文献类型：
--
作者：
Keleg, Shereen;Buchler, Peter;Ludwig, Roman;Buchler, Markus W;Friess, Helmut
胰腺癌仍然是一种具有挑战性的疾病，总体累积5年生存率低于1%。癌症的发生、发展和转移的过程仍然没有很好地理解。侵袭和肿瘤转移密切相关，并且都发生在肿瘤宿主微生态中，其中基质和肿瘤细胞交换酶和细胞因子，其修饰局部细胞外基质，刺激细胞迁移，并促进细胞增殖和肿瘤细胞存活。在过去的十年中，在了解参与局部和全身肿瘤生长的基因的遗传改变方面取得了相当大的进展。最重要的变化发生在调节细胞周期进程、细胞外基质稳态和细胞迁移的基因中。此外，越来越多的证据表明，表观遗传因素包括血管生成和淋巴管生成可能参与肿瘤转移的形成。在这篇综述中，我们强调了参与肿瘤侵袭和转移的最重要的遗传改变，并进一步概述了肿瘤血管生成和淋巴管生成在系统性肿瘤播散中的作用。
Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood well. Invasion and tumor metastasis are closely related and both occur within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate cell migration, and promote cell proliferation and tumor cell survival. During the last decade considerable progress has been made in understanding genetic alterations of genes involved in local and systemic tumor growth. The most important changes occur in genes which regulate cell cycle progression, extracellular matrix homeostasis and cell migration. Furthermore, there is growing evidence that epigenetic factors including angiogenesis and lymphangiogenesis may participate in the formation of tumor metastasis. In this review we highlight the most important genetic alterations involved in tumor invasion and metastasis and further outline the role of tumor angiogenesis and lymphangiogenesis in systemic tumor dissemination.