Bacterial interference caused by autoinducing peptide variants
Bacterial interference caused by autoinducing peptide variants
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DOI：
10.1126/science.276.5321.2027
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发表时间：
1997-06-27
期刊：
影响因子：
56.9
通讯作者：
Novick, RP
中科院分区：
文献类型：
--
作者：
Ji, GY;Beavis, R;Novick, RP
金黄色葡萄球菌的毒力因子和其他胞外蛋白的合成由agr基因座全局控制，该基因座编码双组分信号通路，其活化配体是agr编码的自诱导肽。某些菌株产生的同源肽抑制另一些菌株的agr表达，并且这些菌株之间的肽和受体的氨基酸序列明显不同，这暗示了高变异性产生机制。基因表达的交叉抑制代表了一种类型的细菌干扰，其可能与一种菌株将其他菌株从感染或定殖位点或两者中排除的能力相关。
The synthesis of virulence factors and other extracellular proteins by Staphylococcus aureus is globally controlled by the agr locus, which encodes a two-component signaling pathway whose activating ligand is an agr-encoded autoinducing peptide. The cognate peptides produced by some strains inhibit the expression of agr in other strains, and the amino acid sequences of peptide and receptor are markedly different between such strains, suggesting a hypervariability-generating mechanism. Cross-inhibition of gene expression represents a type of bacterial interference that could be correlated with the ability of one strain to exclude others from infection or colonization sites, or both.