Bioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization.
Bioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization.
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DOI：
10.1002/anie.201908634
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发表时间：
2019-10
影响因子：
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通讯作者：
Hao Sun;Wonmin Choi;Nanzhi Zang;Claudia Battistella;M. Thompson;Wei Cao;Xuhao Zhou;C. Forman;N. Gianneschi
中科院分区：
文献类型：
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作者：
Hao Sun;Wonmin Choi;Nanzhi Zang;Claudia Battistella;M. Thompson;Wei Cao;Xuhao Zhou;C. Forman;N. Gianneschi
Harnessing metal-free photoinduced reversible-deactivation radical polymerization (photo-RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme-responsive and pro-apoptotic peptide brush polymers. Thermolysin-responsive peptide based polymeric amphiphiles assembled into spherical micellar nanoparticles that undergo a morphology transition to worm-like micelles upon enzyme-triggered cleavage of coronal peptide sidechains. Moreover, pro-apoptotic polypeptide brushes show enhanced cell uptake over individual peptide chains of the same sequence, resulting in a significant increase in cytotoxicity to cancer cells. Critically, increased grafting density of pro-apoptotic peptides on brush polymers correlates with increased uptake efficiency and concurrently, cytotoxicity. The mild synthetic conditions afforded by photo-RDRP, make it possible to access well-defined peptide-based polymer bioconjugate structures with tunable bioactivity.
