Risk of Cancer Mortality according to the Metabolic Health Status and Degree of Obesity
Risk of Cancer Mortality according to the Metabolic Health Status and Degree of Obesity
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DOI：
10.7314/apjcp.2014.15.22.10027
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Suh, Mina
中科院分区：
文献类型：
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作者：
Oh, Chang-Mo;Jun, Jae Kwan;Suh, Mina
背景资料：我们使用国家健康保险系统的抽样队列数据，根据肥胖状况和代谢健康状况调查了癌症死亡风险。材料与方法：使用抽样队列数据库（n= 363，881）中的体重指数和空腹血糖数据来估计癌症死亡风险。使用考克斯比例风险模型分析数据（模型1针对年龄、性别、收缩压、舒张压、总胆固醇水平和尿蛋白进行调整;模型2针对模型1加上吸烟状态、酒精摄入和体力活动进行调整）。结果如下：根据肥胖状态，与正常体重组相比，超重组和肥胖组的平均风险比分别为0.82 [95%置信区间（CI），0.75-0.89]和0.79（95%CI，0.72-0.85）。根据代谢健康状况，与代谢健康组相比，代谢不健康组的平均风险比为1.26（95%CI，1.14-1.40）。肥胖状态和代谢健康状态之间的相互作用对癌症死亡率的风险没有统计学意义（p=0.31）。结论：我们发现，癌症死亡的风险根据肥胖状态而降低，根据代谢健康状态而增加。鉴于代谢功能障碍的发生率上升，癌症的死亡率也可能上升。针对代谢功能障碍的治疗策略可能会降低癌症死亡的风险。
Background: We investigated the risk of cancer mortality according to obesity status and metabolic health status using sampled cohort data from the National Health Insurance system. Materials and Methods: Data on body mass index and fasting blood glucose in the sampled cohort database (n=363,881) were used to estimate risk of cancer mortality. Data were analyzed using a Cox proportional hazard model (Model 1 was adjusted for age, sex, systolic blood pressure, diastolic blood pressure, total cholesterol level and urinary protein; Model 2 was adjusted for Model 1 plus smoking status, alcohol intake and physical activity). Results: According to the obesity status, the mean hazard ratios were 0.82 [95% confidence interval (CI), 0.75-0.89] and 0.79 (95% CI, 0.72-0.85) for the overweight and obese groups, respectively, compared with the normal weight group. According to the metabolic health status, the mean hazard ratio was 1.26 (95% CI, 1.14-1.40) for the metabolically unhealthy group compared with the metabolically healthy group. The interaction between obesity status and metabolic health status on the risk of cancer mortality was not statistically significant (p=0.31). Conclusions: We found that the risk of cancer mortality decreased according to the obesity status and increased according to the metabolic health status. Given the rise in the rate of metabolic dysfunction, the mortality from cancer is also likely to rise. Treatment strategies targeting metabolic dysfunction may lead to reductions in the risk of death from cancer.