Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer
Biologically-Targeted Detection of Primary and Micro-Metastatic Ovarian Cancer
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DOI：
10.7150/thno.6413
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发表时间：
2013-01-01
期刊：
影响因子：
12.4
通讯作者：
Zheng, Gang
中科院分区：
文献类型：
--
作者：
Liu, Tracy W.;Stewart, Jocelyn M.;Zheng, Gang
Ovarian cancer is the leading cause of morbidity/mortality from gynecologic malignancy. Early detection of disease is difficult due to the propensity for ovarian cancer to disseminate throughout the peritoneum. Currently, there is no single accurate test to detect primary or recurrent ovarian cancer. We report a novel clinical strategy using PPF: a multimodal, PET and optical, folate receptor (FR)-targeted agent for ovarian cancer imaging. The capabilities of PPF were evaluated in primary human ovarian cancer cells, in vivo xenografts derived from primary cells and ex vivo patient omemtum, as the heterogeneity and phenotype displayed by patients is retained. Primary cells uptake PPF in a FR-dependent manner demonstrating approximately a 5- to 25-fold increase in fluorescence. By both PET and fluorescence imaging, PPF specifically delineated FR-positive, ovarian cancer xenografts, with similar tumor-to-background ratios of 8.91 +/- 0.91 and 7.94 +/- 3.94, and micro-metastatic studding (
