MITOCHONDRIAL GENETICS - A PARADIGM FOR AGING AND DEGENERATIVE DISEASES
MITOCHONDRIAL GENETICS - A PARADIGM FOR AGING AND DEGENERATIVE DISEASES
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DOI：
10.1126/science.1533953
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发表时间：
1992-05-01
期刊：
影响因子：
56.9
通讯作者：
WALLACE, DC
中科院分区：
文献类型：
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作者：
WALLACE, DC
对线粒体 DNA 突变引起的疾病的研究表明，多种退行性过程可能与氧化磷酸化 (OXPHOS) 缺陷有关。这一假设的应用为缺血性心脏病、迟发性糖尿病、帕金森病、阿尔茨海默病和衰老等不同的临床问题提供了新的见解。
Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.