Handling-induced enhancement of alcohol's acute physiological effects.
Handling-induced enhancement of alcohol's acute physiological effects.
复制标题
处理引起的酒精急性生理效应的增强。
DOI：
10.1016/0024-3205(86)90313-9
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发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Cunningham,CL
中科院分区：
文献类型：
--
作者：
Peris,J;Cunningham,CL
轻度应激（处理）加剧了乙醇对大鼠心率和体温的急性影响。尽管乙醇和处理组合产生的心动过速似乎是由于每种条件的单独心动过速效应的简单总和，但热变化代表了单独效应的非累加组合。具体来说，虽然单独处理产生体温过高，但它增强了乙醇诱导的体温过低。血液和大脑中的乙醇水平未因处理而改变。应激诱导的乙醇临界反应的增强可能对酒精耐受性和依赖性的发展具有重要意义。
A mild stressor (handling) exacerbated the acute effects of ethanol on heart rate and body temperature in rats. Although the tachycardia produced by the combination of ethanol and handling appeared to be due to a simple summation of the separate tachycardic effects of each condition, the thermal change represented a nonadditive combination of the separate effects. Specifically, although handling alone produced hyperthermia, it enhanced the hypothermia induced by ethanol. Blood and brain levels of ethanol were not altered by handling. Stress-induced enhancement of critical responses to ethanol may have important implications for the development of tolerance to and dependence on alcohol.