Metabolic markers of cobalamin deficiency and cognitive function in normal older adults
Metabolic markers of cobalamin deficiency and cognitive function in normal older adults
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DOI：
10.1111/j.1532-5415.2004.52012.x
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发表时间：
2004-01-01
影响因子：
6.3
通讯作者：
Roman, GC
中科院分区：
文献类型：
--
作者：
Garcia, AA;Haron, Y;Roman, GC
目的：探讨正常老年人钴胺素缺乏代谢标志物与认知功能之间的关系。设计：横断面研究。环境：加拿大安大略省金斯顿市女王大学和圣玛丽湖医院。参与者：261名认知正常的65岁及以上的社区居民。测定方法：测定血清钴胺素、红细胞叶酸、甲基柠檬酸、同型半胱氨酸和甲基丙二酸。认知工具包括加州语言学习测试、马蒂斯痴呆评定量表和Stroop神经心理筛查量表（Stroop）。结果：调整年龄和性别后，血清甲基柠檬酸水平与加州言语学习测验的回忆、学习和判别性（因子1）呈显著负相关（β =-0.138， P= 0.019）。甲基柠檬酸升高的受试者得分（因子1）明显低于甲基柠檬酸正常的受试者(P
OBJECTIVES: To investigate the relationship between metabolic markers of cobalamin deficiency and cognitive function in normal older adults.DESIGN: Cross-sectional study.SETTING: Queen's University and St. Mary's of the Lake Hospital, Kingston, Ontario, Canada.PARTICIPANTS: Two hundred eighty-one cognitively normal, community-dwelling participants aged 65 and older.MEASUREMENTS: Serum cobalamin, red blood cell folate, methylcitric acid, homocysteine, and methylmalonic acid were determined. Cognitive instruments included the California Verbal Learning Test, Mattis Dementia Rating Scale, and the Stroop Neuropsychological Screening Inventory (Stroop).RESULTS: Serum levels of methylcitric acid had a significant negative correlation with recall, learning, and discriminability (factor 1) of the California Verbal Learning Test after adjusting for age and sex (beta=-0.138, P=.019). Subjects with elevated methylcitric acid had significantly lower scores (factor 1) than subjects with normal methylcitric acid (P