How do mesenchymal stromal cells exert their therapeutic benefit?
How do mesenchymal stromal cells exert their therapeutic benefit?
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DOI：
10.1080/14653240802618085
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发表时间：
2008-01-01
期刊：
影响因子：
4.5
通讯作者：
Dominici, M.
中科院分区：
文献类型：
--
作者：
Horwitz, E. M.;Dominici, M.
近年来，间充质基质细胞（MSC）已成为一种主要的新形式的细胞治疗。虽然最初的看法是MSC是干细胞/祖细胞，具有促进组织再生的潜力，但最近的数据表明，MSC活性的主要机制是通过释放引起观察到的生物反应的可溶性介质。未来的研究需要更全面地确定治疗应用的范围，并更好地描绘相关的分子和细胞机制。
In recent years mesenchymal stromal cells (MSC) have emerged as a major new form of cell therapy. While the original perception was that MSC were stem/progenitor cells with the potential to contribute to the regeneration of tissue, more recent data suggest that the principal mechanism of MSC activity is through the release of soluble mediators that elicit the observed biologic response. Future studies are needed to identify more completely the spectrum of therapeutic applications and delineate better the associated molecular and cellular mechanisms.