Plasma homocysteine and malondialdehyde are correlated in an age- and gender-specific manner
Plasma homocysteine and malondialdehyde are correlated in an age- and gender-specific manner
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DOI：
10.1053/meta.2002.35587
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发表时间：
2002-11-01
影响因子：
9.8
通讯作者：
Roberts, JM
中科院分区：
文献类型：
--
作者：
Powers, RW;Majors, AK;Roberts, JM
同型半胱氨酸是外周血管和冠状动脉疾病的独立危险因素。同型半胱氨酸促进血管功能障碍的确切机制尚不清楚，但推测与氧化应激有关。一些研究调查了同型半胱氨酸在促进氧化应激中的作用，并获得了相互矛盾的结果。这些研究中受试者人群的年龄和性别可能会影响结局。因此，我们研究了血浆同型半胱氨酸浓度是否与血浆丙二醛（MIDA，氧化应激的标志物）相关，以及受试者的年龄和性别是否影响这种相关性。血浆同型半胱氨酸和MDA测定35例绝经前妇女，14例青年男子，38例绝经后妇女，18例老年男子。同型半胱氨酸在男性中显著高于女性（P <0.01），在老年人中显著高于年轻人。然而，MDA仅在年轻男性中显著更高（P <0.01）。此外，仅在这些年轻男性中同型半胱氨酸和MDA之间存在显著相关性（R-2 = 0.50，P <0.01）。最后，接受甲硫氨酸负荷的受试者没有表现出MDA增加，尽管同型半胱氨酸显著增加。由于氧化应激仅在年轻男性中与基础同型半胱氨酸相关，并且不会随着同型半胱氨酸的急性增加而增加，因此不太可能是同型半胱氨酸直接作用的结果。版权所有2002，爱思唯尔科学（美国）。All rights reserved.
Homocysteine is an independent risk factor for peripheral vascular and coronary artery disease. The exact mechanism by which homocysteine promotes vascular dysfunction is unclear, but it is speculated to involve oxidative stress. Several studies have investigated the role of homocysteine in promoting oxidative stress and have obtained conflicting results. The age and gender of the subject populations in these studies may have influenced the outcome. Therefore, we investigated whether plasma homocysteine concentrations were correlated with plasma malondialdehyde (MIDA, a marker of oxidative stress), and if the subject's age and gender affected this correlation. Plasma homocysteine and MDA were measured in 35 premenopausal women, 14 young men, 38 postmenopausal women, and 18 older men. Homocysteine was significantly higher in men than women (P < .01) and in older subjects versus younger. However, MDA was significantly greater only in the young men (P < .01). Furthermore, there was a significant correlation between homocysteine and MDA only in these young men (R-2 = 0.50, P < .01). Lastly, subjects undergoing a methionine load did not exhibit increased MDA despite significant increases in homocysteine. Since oxidative stress correlates with basal homocysteine only in young men and does not increase with acutely increased homocysteine, it is unlikely to be the result of a direct effect of homocysteine. Copyright 2002, Elsevier Science (USA). All rights reserved.