Reduced induction of human β-defensins is involved in the pathological mechanism of cutaneous adverse effects caused by epidermal growth factor receptor monoclonal antibodies.
Reduced induction of human β-defensins is involved in the pathological mechanism of cutaneous adverse effects caused by epidermal growth factor receptor monoclonal antibodies.
复制标题
人β-防御素诱导减少参与表皮生长因子受体单克隆抗体引起皮肤不良反应的病理机制。
DOI：
10.1111/ced.14311
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发表时间：
2020
影响因子：
4.1
通讯作者：
Asada H
中科院分区：
文献类型：
--
作者：
Ommori R;Nakamura Y;Miyagawa F;Shobatake C;Ogawa K;Koyama F;Sho M;Ota I;Kitahara T;Hontsu S;Muro S;Asada H
表皮生长因子受体抑制剂（EGFRI）经常引起皮肤不良反应，如丘疹脓疱性皮疹。然而，这些反应的机制仍不清楚。为了评估表皮生长因子受体抑制剂引起皮肤不良反应的病理机制，我们研究了表皮生长因子受体抑制剂是否对皮肤的先天免疫反应有影响。EGFR治疗患者角质层样本中人β-防御素（hBD）水平，hBD作为抵抗病原微生物感染的第一道防线。在开始治疗之前和之后测量单克隆抗体。在无皮疹的患者中hBD的产生没有明显的趋势，而在发生丘疹脓疱性皮疹的患者中观察到hBD 1和hBD 3的产生显著减少，hBD 2的产生无显著减少。我们的研究结果表明，减少hBD有助于增加丘疹脓疱性皮疹的发病率。
Epidermal growth factor receptor inhibitors (EGFRIs) frequently cause cutaneous adverse effects such as papulopustular eruptions. However, the mechanism of the reactions remains unclear. To assess the pathological mechanism of cutaneous adverse reactions caused by EGFRIs, we investigated whether EGFRIs have an influence on the innate immune response of the skin. Levels of human β‐defensins (hBDs), which serve as the first line of defence against infection by pathogenic microorganisms, in the stratum corneum samples of patients treated with EGFR. monoclonal antibodies were measured before and after starting therapy. There were no obvious trends in hBD production in patients without eruptions, whereas a significant decrease in hBD1 and hBD3 production and a nonsignficant decrease in hBD2 production were observed in patients who developed papulopustular eruptions. Our results suggest that a reduction in hBD contributes to the increased incidence of papulopustular eruptions.