A new isoflavone derivative from Streptomyces sp YIM GS3536
A new isoflavone derivative from Streptomyces sp YIM GS3536
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来自链霉菌 YIM GS3536 的新异黄酮衍生物
DOI：
10.1007/s10600-013-0440-4
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发表时间：
2013-01-01
影响因子：
0.8
通讯作者：
Wen, Meng-Liang
中科院分区：
文献类型：
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作者：
Huang, Rong;Ding, Zhang-Gui;Wen, Meng-Liang
从云南土壤样品中分离得到链霉菌YIM GS3536的代谢产物，并与8-氯染料木素(2)、kakkatin(3)、7- o -甲基染料木素(4)、染料木素(5)、大豆苷元(6)、甘糖素(7)、genistin(8)、大豆苷元(9)等8种已知异黄酮化合物一起分离得到新的天然产物7- o -甲基-8-绿染料木素(1)。我们报告了新化合物7- o -甲基-8-绿染料木黄酮的H-1和C-13 NMR谱的明确分配(1)。化合物1对人黑色素瘤细胞株（B16）和人白血病细胞株（HL60）具有明显的细胞毒性，IC50值分别为17.5 μ M和19.2 μ M。枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和白色念珠菌的MIC值为1，在23 ~ 35 μ M之间。
A new natural product named 7-O-methyl-8-chlorogenistein (1) was isolated together with eight known isoflavones, 8-chlorogenistein (2), kakkatin (3), 7-O-methyl genistein (4), genistein (5), daidzein (6), glycitin (7), genistin (8), and daidzin (9), from the metabolites of Streptomyces strain YIM GS3536, which was isolated from soil sample collected from Yunnan Province, China. We report the unambiguous assignments of the H-1 and C-13 NMR spectra of the new compound 7-O-methyl-8-chlorogenistein (1). Compound 1 exhibited appreciable cytotoxicity against human melanoma cell lines (B16) and human leukemia cell lines (HL60) with IC50 values of 17.5 and 19.2 mu M, respectively. The MIC values of 1 for Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were in the range of 23-35 mu M.