Morphologic changes in lungs of anesthetized sheep following intravenous infusion of recombinant tumor necrosis factor alpha.
Morphologic changes in lungs of anesthetized sheep following intravenous infusion of recombinant tumor necrosis factor alpha.
复制标题
静脉输注重组肿瘤坏死因子α后麻醉羊肺部的形态变化。
DOI：
10.1164/ajrccm/144.1.179
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Meyrick,B
中科院分区：
文献类型：
--
作者：
Johnson,J;Brigham,KL;Jesmok,G;Meyrick,B
Tumor necrosis factor a (TNFa) is a monokine released in response to endotoxin and has been suggested as a primary mediator of endotoxic shock. We have recently demonstrated that infusion of recombinant human tumor necrosis factor a (rTNFa) into sheep elicits a physiologic response in the lung that closely resembles endotoxemia. The present study examines the morphologic changes that accompany these alterations in pulmonary physiology. Five anesthetized, openchest sheep received 0.01 mg/kg of protein (2.24 x 107 U rTNFalmg) intravenously over 30 min.
