Serum Concentrations of Antibodies against Outer Membrane Protein P6, Protein D, and T- and B-Cell Combined Antigenic Epitopes of Nontypeable Haemophilus influenzae in Children and Adults of Different Ages
Serum Concentrations of Antibodies against Outer Membrane Protein P6, Protein D, and T- and B-Cell Combined Antigenic Epitopes of Nontypeable Haemophilus influenzae in Children and Adults of Different Ages
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DOI：
10.1128/cvi.00506-15
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发表时间：
2016-02-01
影响因子：
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通讯作者：
Yan, Jie
中科院分区：
文献类型：
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作者：
Hua, Chun-Zhen;Hu, Wei-Lin;Yan, Jie
无法分型的流感嗜血杆菌（NTHi）是急性中耳炎、鼻窦炎和肺炎的最常见病因之一。外膜蛋白（OMPs）是NTHi新疫苗开发的主要焦点，如H. B型流感（HiB）疫苗不包括非胶囊化NTHi。OMPs P6和蛋白D是NTHi疫苗最有希望的候选抗原，血清中针对它们的低抗体水平可能与NTHi引起的感染相关。在目前的研究中，我们测量了不同年龄的健康个体中针对P6、蛋白D及其T细胞和B细胞结合肽表位的抗体滴度。我们发现孩子们
Nontypeable Haemophilus influenzae (NTHi) is one of the most common etiologies of acute otitis media, rhinosinusitis, and pneumonia. Outer membrane proteins (OMPs) are the main focus in new vaccine development against NTHi, as the H. influenzae type b (Hib) vaccine does not cover noncapsulated NTHi. The OMPs P6 and protein D are the most promising candidate antigens for an NTHi vaccine, and low antibody levels against them in serum may be correlated with infection caused by NTHi. In the current study, we measured the antibody titers against P6, protein D, and their T-and B-cell combined peptide epitopes in healthy individuals of different ages. We found that children