Cell integrity signaling activation in response to hyperosmotic shock in yeast
Cell integrity signaling activation in response to hyperosmotic shock in yeast
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DOI：
10.1016/j.febslet.2005.10.001
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发表时间：
2005-11-07
期刊：
影响因子：
3.5
通讯作者：
Roncero, C
中科院分区：
文献类型：
--
作者：
García-Rodríguez, LJ;Valle, R;Roncero, C
目前的进展突出了酵母细胞壁作为一个高度动态的结构，响应许多环境压力的作用。在这里，我们表明，高渗休克瞬时激活PKC信号通路，需要事先激活HOG通路的反应。在这样的条件下，磷酸化的Slt2p的甘油营业额的变化有关，主要是Mid2p依赖性，这表明细胞膨压的变化，介导的细胞内积累的甘油，由PKC传感器，以促进细胞的完整性反应。这些观察结果，加上以前的结果，表明酵母细胞通过重塑细胞壁来响应细胞膨压的变化。(c)2005年由Elsevier B.V.代表欧洲生物化学学会联合会出版。
Current progress highlights the role of the yeast cell wall as a highly dynamic structure that responds to many environmental stresses. Here, we show that hyperosmotic shock transiently activates the PKC signaling pathway, a response that requires previous activation of the HOG pathway. Phosphorylation of Slt2p under such conditions is related to changes in the glycerol turnover and is mostly Mid2p dependent, suggesting that changes in cell turgor, mediated by intracellular accumulation of glycerol, are sensed by PKC sensors to promote the cell integrity response. These observations, together with previous results, suggest that yeast cells respond to changes in cellular turgor by remodeling their cell walls. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.