New insights into vinculin function and regulation.
New insights into vinculin function and regulation.
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对Vinculin功能和调节的新见解。
DOI：
10.1016/b978-0-12-386043-9.00005-0
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发表时间：
2011
影响因子：
--
通讯作者：
DeMali, Kris A.
中科院分区：
文献类型：
--
作者：
Peng, Xiao;Nelson, Elke S.;Maiers, Jessica L.;DeMali, Kris A.
Vinculin是一种细胞质肌动蛋白结合蛋白，富集于局灶黏附和黏附连接中，对胚胎发育至关重要。现在对血管蛋白在控制细胞-基质粘附中的作用已经有了很多了解。在过去的十年中，关于血管蛋白的晶体结构和血管蛋白如何调控粘附事件的分子细节已经出现。最近的数据表明，在调节整合素聚集，力的产生和粘附强度的关键功能。除了在细胞-基质粘附中发挥重要作用外，血管蛋白还作为细胞凋亡、志贺氏菌进入宿主细胞和钙粘蛋白基细胞-细胞粘附的调节剂出现。对这项工作的仔细检查表明，在局灶黏附和这些过程中，白细胞蛋白的作用有相似之处，也有一些有趣的差异。
Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens junctions that is essential for embryonic development. Much is now known regarding the role of vinculin in governing cell–matrix adhesion. In the past decade that the crystal structure of vinculin and the molecular details for how vinculin regulates adhesion events have emerged. The recent data suggests a critical function for vinculin in regulating integrin clustering, force generation, and strength of adhesion. In addition to an important role in cell– matrix adhesion, vinculin is also emerging as a regulator of apoptosis, Shigella entry into host cells, and cadherin-based cell–cell adhesion. A close inspection of this work reveals that there are similarities between vinculin’s role in focal adhesions and these processes and also some intriguing differences.
人血小板质蛋白的隔离和部分表征。
影响因子：
7.8
作者：
Rosenfeld, G C;Hou, D C;Dingus, J;Meza, I;Bryan, J
通讯作者：
Bryan, J