Plasma Cytokine Levels in Tanzanian HIV-1-Infected Adults and the Effect of Antiretroviral Treatment
Plasma Cytokine Levels in Tanzanian HIV-1-Infected Adults and the Effect of Antiretroviral Treatment
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DOI：
10.1097/qai.0b013e3181b627dc
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发表时间：
2009-12-01
影响因子：
3.6
通讯作者：
Ullum, Henrik
中科院分区：
文献类型：
--
作者：
Haissman, Judith M.;Vestergaard, Lasse S.;Ullum, Henrik
目的：为了评价免疫激活导致细胞因子的产生和循环在撒哈拉以南非洲HIV感染发病机制中的作用以及抗逆转录病毒治疗（ART）对这些参数的影响，方法：血浆肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6、IL-8、单核细胞趋化蛋白（MCP）-1、IL-10和IL-1受体拮抗剂浓度;血红蛋白浓度;在坦桑尼亚东北部，对229名艾滋病毒感染者、54名艾滋病毒未感染者以及分别接受ART 2个月和4个月后的35名符合条件的个人进行了检测，并测量了白色血细胞。结果：肿瘤坏死因子-α、IL-6、IL-8、单核细胞趋化蛋白-1、和IL-1受体拮抗剂在HIV感染者中显著高于HIV未感染者，感染者的CD 4细胞计数低于每微升200个细胞，而感染者的CD 4细胞计数高于每微升200个细胞。在多变量分析中，HIV RNA是所有细胞因子表达的最强预测因子。ART导致所有细胞因子减少到接近那些HIV-uninfected individual.Conclusions的水平：我们的研究结果支持HIV病毒复制的免疫激活的最重要的促进剂的作用，并证明了ART在减少免疫激活和病毒复制的重要性，即使在撒哈拉以南非洲，患者暴露于丰富的其他传染性病原体。
Objective: To evaluate the role immune activation leading to the production and circulation of cytokines has in the pathogenesis of HIV infection in sub-Saharan Africa and the effect of antiretroviral treatment (ART) on these parameters.Methods: Plasma concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, IL-10, and IL-1 receptor antagonist; plasma HIV RNA; hemoglobin concentration; and white blood cells were measured in 229 HIV-infected, 54 HIV-uninfected, and after 2 and 4 months, respectively, of ART in 35 eligible individuals in northeastern Tanzania.Results: Plasma levels of tumor necrosis factor-alpha, IL-6, IL-8, monocyte chemotactic protein-1, and IL-1 receptor antagonist were significantly higher in HIV-infected individuals compared with HIV-uninfected individuals and also significantly higher in HIV-infected individuals with CD4 cell counts below 200 cells per microliter than individuals with CD4 cell counts above 200 cells per microliter. HIV RNA was the strongest predictor of all cytokine expression in multivariate analysis. ART leads to a decrease in all cytokines to levels close to those of HIV-uninfected individuals.Conclusions: Our findings support the role of HIV viral replication as the most important promoter of immune activation and prove the importance of ART in reducing immune activation and viral replication even in sub-Saharan Africa where patients are-exposed to an abundance of other infectious agents.