Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis.
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DOI：
10.1038/nrmicro.2016.87
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Fodor E
中科院分区：
文献类型：
--
作者：
Te Velthuis AJ;Fodor E
流感病毒的基因组由多个单链负义RNA片段组成。每个片段都与异源三聚体病毒 RNA 依赖性 RNA 聚合酶和核蛋白的多个拷贝结合，形成病毒核糖核蛋白 (vRNP) 复合物。正是在这些 vRNP 的背景下，病毒 RNA 聚合酶进行病毒基因的转录和病毒 RNA 基因组的复制。在这篇综述中，我们讨论了我们目前对流感病毒 RNA 聚合酶结构的了解，它如何进行转录和复制，以及它的活性如何受到病毒和宿主因素的调节。此外，我们讨论了我们对聚合酶功能理解的进步如何帮助识别新的抗病毒靶点。
The genome of influenza viruses consists of multiple segments of single stranded negative-sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent RNA polymerase and multiple copies of nucleoprotein, forming viral ribonucleoprotein (vRNP) complexes. It is in the context of these vRNPs that the viral RNA polymerase carries out transcription of viral genes and replication of the viral RNA genome. In this Review, we discuss our current knowledge of the structure of the influenza virus RNA polymerase, how it carries out transcription and replication, and how its activities are modulated by viral and host factors. Furthermore, we discuss how advances in our understanding of polymerase function could help identifying new antiviral targets.