Long-Term Ambient Residential Traffic-Related Exposures and Measurement Error-Adjusted Risk of Incident Lung Cancer in the Netherlands Cohort Study on Diet and Cancer.
Long-Term Ambient Residential Traffic-Related Exposures and Measurement Error-Adjusted Risk of Incident Lung Cancer in the Netherlands Cohort Study on Diet and Cancer.
复制标题
DOI：
10.1289/ehp.1408762
复制
发表时间：
2015-09
影响因子：
10.4
通讯作者：
van den Brandt P
中科院分区：
文献类型：
--
作者：
Hart JE;Spiegelman D;Beelen R;Hoek G;Brunekreef B;Schouten LJ;van den Brandt P
国际癌症研究机构（IARC）最近宣布空气污染对人类致癌。然而，到目前为止，还没有关于空气污染和肺癌的研究纳入了对暴露测量误差的调整，也很少有研究具体的组织学亚型。我们的目的是评估荷兰饮食与癌症队列研究中空气污染与肺癌发病率之间的关联，以及测量误差对这些关联的影响。研究人员从1986年到2003年对这群人进行了随访，确定了3355例病例。Cox比例风险模型用于估计长期暴露于二氧化氮（NO2）、黑烟（BS）、PM2.5（直径≤2.5 μm的颗粒物）以及道路邻近度和交通量的风险比和95%置信区间，并对潜在混杂因素进行了调整。来自先前验证研究的信息被用于校正测量误差的效应估计。我们观察到暴露于BS的患者发生肺癌的风险升高[危险比(HR) = 1.16；95% CI: 1.02, 1.32，每10 μg/m3]， NO2 (HR = 1.29; 95% CI: 1.08, 1.54，每30 μg/m3), PM2.5 (HR = 1.17; 95% CI: 0.93, 1.47，每10 μg/m3)，以及基线地址的交通测量。暴露与所有肺癌亚型呈正相关。校正测量误差后，HR增加，95% CI变宽[BS的HR = 1.19 (95% CI: 1.02, 1.39), PM2.5的HR = 1.37 (95% CI: 0.86, 2.17)]。这些发现为越来越多关于空气污染对肺癌影响的文献提供了支持。此外，它们强调了污染物测量误差的变化，并支持在可能的情况下实施测量误差修正。李建军，李建军，李建军，李建军，李建军，李建军，李建军，李建军。荷兰饮食与癌症队列研究中长期环境住宅交通相关暴露和测量误差调整后的肺癌发生风险环境健康展望123:860-866；http://dx.doi.org/10.1289/ehp.1408762
The International Agency for Research on Cancer (IARC) recently declared air pollution carcinogenic to humans. However, no study of air pollution and lung cancer to date has incorporated adjustment for exposure measurement error, and few have examined specific histological subtypes. Our aim was to assess the association of air pollution and incident lung cancer in the Netherlands Cohort Study on Diet and Cancer and the impact of measurement error on these associations. The cohort was followed from 1986 through 2003, and 3,355 incident cases were identified. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals, for long-term exposures to nitrogen dioxide (NO2), black smoke (BS), PM2.5 (particulate matter with diameter ≤ 2.5 μm), and measures of roadway proximity and traffic volume, adjusted for potential confounders. Information from a previous validation study was used to correct the effect estimates for measurement error. We observed elevated risks of incident lung cancer with exposure to BS [hazard ratio (HR) = 1.16; 95% CI: 1.02, 1.32, per 10 μg/m3], NO2 (HR = 1.29; 95% CI: 1.08, 1.54, per 30 μg/m3), PM2.5 (HR = 1.17; 95% CI: 0.93, 1.47, per 10 μg/m3), and with measures of traffic at the baseline address. The exposures were positively associated with all lung cancer subtypes. After adjustment for measurement error, the HRs increased and the 95% CIs widened [HR = 1.19 (95% CI: 1.02, 1.39) for BS and HR = 1.37 (95% CI: 0.86, 2.17) for PM2.5]. These findings add support to a growing body of literature on the effects of air pollution on lung cancer. In addition, they highlight variation in measurement error by pollutant and support the implementation of measurement error corrections when possible. Hart JE, Spiegelman D, Beelen R, Hoek G, Brunekreef B, Schouten LJ, van den Brandt P. 2015. Long-term ambient residential traffic–related exposures and measurement error–adjusted risk of incident lung cancer in the Netherlands Cohort Study on Diet and Cancer. Environ Health Perspect 123:860–866; http://dx.doi.org/10.1289/ehp.1408762