CYTO-TOXIC T-CELL RESPONSE TO RESPIRATORY SYNCYTIAL VIRUS IN MICE
CYTO-TOXIC T-CELL RESPONSE TO RESPIRATORY SYNCYTIAL VIRUS IN MICE
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DOI：
10.1128/jvi.56.1.55-59.1985
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发表时间：
1985-01-01
影响因子：
5.4
通讯作者：
ASKONAS, BA
中科院分区：
文献类型：
--
作者：
BANGHAM, CRM;CANNON, MJ;ASKONAS, BA
免疫应答的体液和细胞臂在保护免受呼吸道合胞病毒（RSV）感染和在该疾病的严重形式的发病机制中的作用知之甚少。最近证明，一些近交系小鼠品系可以感染RSV开辟了道路，详细调查RSV免疫。我们在这里报告的主要组织相容性复合物限制性，RSV特异性记忆细胞毒性T细胞的BALB/c和C57 BL小鼠鼻内感染后的脾脏中的发现，这些T细胞识别长，A2，和8/60（人）株的RSV。K和D基因座主要组织相容性复合体等位基因均可限制细胞毒性反应;然而，在检测的两种单倍型中，Dd是RSV的低应答等位基因，Kb是RSV的无应答等位基因。UV灭活的RSV（当腹膜内给予时）可以引发小鼠细胞毒性T细胞记忆的发展，在体外再刺激细胞毒性T细胞培养物，并形成细胞毒性细胞的靶标。
The role of the humoral and cellular arms of the immune response in protection against respiratory syncytial virus (RSV) infection and in the pathogenesis of the severe forms of this disease is poorly understood. The recent demonstration that some inbred mouse strains can be infected with RSV has opened the way to a detailed investigation of RSV immunity. We report here the finding of major histocompatibility complex-restricted, RSV-specific memory cytotoxic T cells in the spleens of BALB/c and C57BL mice after intranasal infection; these T cells recognize the Long, A2, and 8/60 (human) strains of RSV. Both K and D locus major histocompatibility complex alleles can restrict the cytotoxic response; however, in the two haplotypes tested, Dd is a low-responder allele and Kb is a nonresponder allele for RSV. UV-inactivated RSV (when given intraperitoneally) can prime mice for development of cytotoxic T cell memory, restimulate cytotoxic T cell cultures in vitro, and form a target for the cytotoxic cells.