The effect of dietary protein on the clearance of allopurinol and oxypurinol.
The effect of dietary protein on the clearance of allopurinol and oxypurinol.
复制标题
膳食蛋白质对别嘌呤醇和奥昔嘌呤清除率的影响。
DOI：
10.1056/nejm198509263131302
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Spector,R
中科院分区：
文献类型：
--
作者：
Berlinger,WG;Park,GD;Spector,R
A decrease in dietary protein is known to depress renal plasma flow and creatinine clearance. Using a randomized crossover design, we investigated the pharmacokinetics of allopurinol and its principal metabolite, oxypurinol, after oral administration of 600 mg of allopurinol in six normal subjects receiving a high-protein (268 g per day) or low-protein (19 g per day) diet. For allopurinol, the area under the curve of plasma concentration versus time increased by a factor of 1.45 (P<0.02), the renal clearance decreased by 28 per cent (P<0.02), and the ratio of the clearance of allopurinol to that of creatinine (fractional excretion) was unchanged between the low-protein and high-protein diets. For oxypurinol, the area under the curve increased nearly threefold (P<0.02), the renal clearance decreased by 64 per cent (P<0.02), the fractional excretion decreased by 49 per cent (P<0.02), and the plasma oxypurinol half-life increased nearly threefold from 17.3±1.5(mean ±S.E.M.) to 49.9±2.9 hours (P<0.02) during the low-protein diet, as compared with the high-protein diet. We conclude that with the low-protein diet, the absorption, metabolism, and excretion of allopurinol were minimally altered but the total-body clearance of oxypurinol was greatly reduced because of a large increase in the net renal tubular reabsorption of oxypurinol. (N Engl J Med 1985; 313: 771–6.)
