The anti-addiction drug ibogaine and the heart: a delicate relation.
The anti-addiction drug ibogaine and the heart: a delicate relation.
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DOI：
10.3390/molecules20022208
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发表时间：
2015-01-29
期刊：
影响因子：
--
通讯作者：
Hilber K
中科院分区：
文献类型：
--
作者：
Koenig X;Hilber K
植物吲哚类生物碱伊博格碱在动物实验中显示出有希望的抗成瘾特性。伊博格碱还具有抗成瘾作用，因为它可以减轻对毒品的渴望，并阻止毒品的复发。尽管没有作为治疗药物获得许可，尽管存在安全问题，伊博加因目前在全球数十家诊所被用作替代医学的抗成瘾药物。近年来，有关危及生命的并发症和猝死病例的令人震惊的报告不断增加，这些病例暂时与服用伊博加因有关。这些不良反应被认为与伊博加因诱发心律失常的倾向有关。本综述的目的是总结目前关于伊博加因对心脏和心血管系统影响的知识，并评估在抗成瘾治疗中使用这种药物的心脏风险。18-甲氧基冠状苯胺（18-MC）的作用也被考虑，它是一种毒性较小的伊博加因同系物，具有抗成瘾特性。
The plant indole alkaloid ibogaine has shown promising anti-addictive properties in animal studies. Ibogaine is also anti-addictive in humans as the drug alleviates drug craving and impedes relapse of drug use. Although not licensed as therapeutic drug and despite safety concerns, ibogaine is currently used as an anti-addiction medication in alternative medicine in dozens of clinics worldwide. In recent years, alarming reports of life-threatening complications and sudden death cases, temporally associated with the administration of ibogaine, have been accumulating. These adverse reactions were hypothesised to be associated with ibogaine’s propensity to induce cardiac arrhythmias. The aim of this review is to recapitulate the current knowledge about ibogaine’s effects on the heart and the cardiovascular system, and to assess the cardiac risks associated with the use of this drug in anti- addiction therapy. The actions of 18-methoxycoronaridine (18-MC), a less toxic ibogaine congener with anti-addictive properties, are also considered.
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影响因子：
5
作者：
Glick, Stanley D.;Sell, Elizabeth M.;McCallum, Sarah E.;Maisonneuve, Isabelle M.
通讯作者：
Maisonneuve, Isabelle M.
影响因子：
3.4
作者：
Coller, Janet K.;Michalakas, Jennifer R.;Somogyi, Andrew A.
通讯作者：
Somogyi, Andrew A.
DOI：
10.1111/j.1749-6632.2000.tb05210.x
发表时间：
2000-01-01
期刊：
NEUROBIOLOGICAL MECHANISMS OF DRUGS OF ABUSE: COCAINE, IBOGAINE, AND SUBSTITUTED AMPHETAMINES
影响因子：
--
作者：
Baumann, MH;Pablo, JP;Mash, DC
通讯作者：
Mash, DC
影响因子：
2.9
作者：
Glue, Paul;Lockhart, Michelle;Friedhoff, Lawrence
通讯作者：
Friedhoff, Lawrence
影响因子：
15.9
作者：
Guo, Jun;Massaeli, Hamid;Zhang, Shetuan
通讯作者：
Zhang, Shetuan