ALCOHOLIC RHABDOMYOLYSIS - AN EXPERIMENTAL-MODEL IN THE RAT
ALCOHOLIC RHABDOMYOLYSIS - AN EXPERIMENTAL-MODEL IN THE RAT
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DOI：
10.1126/science.7189294
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
DRACHMAN, DB
中科院分区：
文献类型：
--
作者：
HALLER, RG;DRACHMAN, DB
酒精性横纹肌溶解症的主要特征骨骼肌坏死，血清肌酸磷酸激酶的显着升高，肌红蛋白尿症，在大鼠中产生的组合相对较长时间（2至4周）暴露于乙醇和短暂的食物剥夺。这一观察结果表明，禁食可能同样会引发肌肉损伤，在狂饮man.The影响禁食是部分相关的血液酒精增加，由于减少酒精清除率和部分由禁食引起的高浓度酒精的骨骼肌的毒性作用增强。
The main features of alcoholic rhabdomyolysis-skeletal muscle necrosis, marked elevation of serum creatine phosphokinase, and myoglobinuria-were produced in rats by a combination of relatively prolonged (2 to 4 weeks) exposure to ethanol and a brief period of food deprivation. This observation suggests that fasting may similarly trigger muscle injury during binge drinking in man. The effect of fasting is in part related to an increase in blood alcohol due to reduced alcohol clearance and in part caused by a fasting-induced potentiation of the toxic effects of high concentrations of alcohol of skeletal muscle.