Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance
Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance
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DOI：
10.1182/blood-2008-12-192575
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发表时间：
2009-07-23
期刊：
影响因子：
20.3
通讯作者：
Rajkumar, S. Vincent
中科院分区：
文献类型：
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作者：
Vachon, Celine M.;Kyle, Robert A.;Rajkumar, S. Vincent
我们研究了在多发性骨髓瘤（MM）或MGUS患者的一级亲属中，意义不明的单克隆丙种球蛋白病（MGUS）是否增加。先证者是从基于人群的患病率研究（MGUS）和马约诊所（MM）招募的。血清样本收集自40岁以上的一级亲属，并进行电泳和免疫固定。亲属中MGUS的患病率与基于人群的患病率进行比较。研究了232名MM和97名MGUS先证者的911名亲属。通过电泳，MGUS在55例（6%）亲属中检测到，免疫固定法确定了另外28例亲属，年龄和性别校正的患病率为8.1%（95%CI，6.3至9.8）。亲属MGUS患病率随年龄增长而增加（40-49岁、50-59岁、60-69岁、70-79岁、≥ 80岁年龄组分别为1.9%、6.9%、11.6%、14.6%、21.0%; P
We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6%) relatives, and immunofixation identified 28 additional relatives for an age-and sex-adjusted prevalence of 8.1% (95% CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9%, 6.9%, 11.6%, 14.6%, 21.0% for ages 40-49, 50-59, 60-69, 70-79, >= 80 years, respectively; P