Basal release of ATP: an autocrine-paracrine mechanism for cell regulation.
Basal release of ATP: an autocrine-paracrine mechanism for cell regulation.
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DOI：
10.1126/scisignal.3104re1
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发表时间：
2010-01-12
影响因子：
7.3
通讯作者：
Insel PA
中科院分区：
文献类型：
--
作者：
Corriden R;Insel PA
Cells release adenosine triphosphate (ATP), which activates plasma membrane–localized P2X and P2Y receptors and thereby modulates cellular function in an autocrine or paracrine manner. Release of ATP and the subsequent activation of P2 receptors help establish the basal level of activation (sometimes termed “the set point”) for signal transduction pathways and regulate a wide array of responses that include tissue blood flow, ion transport, cell volume regulation, neuronal signaling, and host-pathogen interactions. Basal release and autocrine or paracrine responses to ATP are multifunctional and evolutionarily conserved, and they provide an economical means for the modulation of cell, tissue, and organismal biology.
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