Impact of Immunosuppression on Recall Immune Responses to Influenza Vaccination in Stable Renal Transplant Recipients
Impact of Immunosuppression on Recall Immune Responses to Influenza Vaccination in Stable Renal Transplant Recipients
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DOI：
10.1097/01.tp.0000438024.10375.2d
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发表时间：
2014-04-27
期刊：
影响因子：
6.2
通讯作者：
Chong, Anita S.
中科院分区：
文献类型：
--
作者：
Cowan, Michelle;Chon, W. James;Chong, Anita S.
背景。美国移植学会建议在肾移植后 3 至 6 个月内每年接种三价灭活流感疫苗，这提供了一个独特的机会来测试免疫抑制对流感疫苗接种后 T 细胞和 B 细胞反应的体内影响。本研究利用人类外周血 B 细胞反应单细胞定量方面的最新突破，前瞻性评估 23 名稳定肾移植受者和 22 名健康对照者对季节性（2010 年和 2011 年）流感疫苗的 B 细胞和 T 细胞反应。结果和结论。结果表明，与健康对照相比，稳定的移植受者对流感疫苗接种的早期 B 细胞反应（通过外周血中流感特异性抗体分泌细胞 (ASC) 的频率进行量化）显着降低。血清反应的程度和血清转化率也减弱了。移植受者中流感特异性干扰素-γ (IFNF) T 细胞反应显着降低；然而，流感特异性 IgG ASC 和 IFNF 反应的强度之间没有相关性。记忆 T 细胞和 B 细胞对流感疫苗接种反应的诱导支持了接种疫苗的建议，而反应减弱则证明了免疫抑制在控制个体移植受者记忆反应方面的功效。
Background. The recommendation by the American Society of Transplantation for annual trivalent inactivated influenza vaccination greater than 3 to 6 months post-kidney transplantation provides a unique opportunity to test the in vivo impact of immunosuppression on recall T- and B-cell responses to influenza vaccination.Methods. This study took advantage of recent breakthroughs in the single-cell quantification of human peripheral blood B-cell responses to prospectively evaluate both B- and T-cell responses to the seasonal (2010 and 2011) influenza vaccine in 23 stable renal transplant recipients and 22 healthy controls.Results and Conclusion. The results demonstrate that the early B-cell response to influenza vaccination, quantified by the frequency of influenza-specific antibody-secreting cells (ASC) in peripheral blood, was significantly reduced in stable transplant recipients compared to healthy controls. The magnitude of the seroresponse and the rate of sero-conversion were also blunted. The influenza-specific interferon-gamma (IFNF) T-cell response was significantly reduced in transplant recipients; however, there was no correlation between the magnitude of the influenza-specific IgG ASC and IFNF responses. The induction of memory T- and B-cell responses to influenza vaccination supports the recommendation to vaccinate while the blunted responses demonstrate the efficacy of immunosuppression in controlling memory responses individual transplant recipients.