Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisins on esophageal cancer risks
Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisins on esophageal cancer risks
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DOI：
10.1002/ijc.22199
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发表时间：
2006-12-15
影响因子：
6.4
通讯作者：
Wu, Ming-Tsang
中科院分区：
文献类型：
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作者：
Chen, Yun-Ju;Chen, Chu;Wu, Ming-Tsang
在我们之前的研究中，我们发现酒精和乙醛脱氢酶(ADH1B和ALDH2)的多态是台湾人群中食道鳞状细胞癌的重要危险因素。在这项研究中，我们增加了样本量，以调查终生饮酒对ADH1B和ALDH2基因与食道癌风险的相关性的影响。2000年8月至2004年6月间进行了一项以医院为基础的多中心病例对照研究。330例新诊断的食管鳞癌患者来自台北的国立台湾大学医院和台湾高雄的高雄退伍军人总医院和高雄医科大学医院。对照组与病例患者的性别和年龄在4年内匹配(病例：对照组=1：1-4)。采用聚合酶链式反应-限制性片段长度多态性方法对ADH1B和ALDH2基因进行了基因分型。在调整适当的协变量后，携带ADH1B*1/*1基因的个体患食道癌的风险是携带ADH1B*2/*2基因个体的3.99倍(95%CI=2.13-7.48)。在调整适当的协变量后，携带ALDH2*1/*2和ALDH2*2/*2的个体患食道癌的风险分别是携带ALDH2*1/*2和ALDH2*1/2的个体的4.99倍(95%CI=3.11-7.99)和4.24倍(95%CI=1.52-11.84)。我们还发现，终生饮酒对ADH1B和ALDH2基因与食道癌风险之间的关联具有修正作用。这些结果提示ADH1B和ALDH2基因多态在食道癌发病中起关键作用，并且这些多态的作用被饮酒量所改变。(C)2006年Wiley-Liss，Inc.
In our previous study, we found that polymorphisms of alcohol and aldehyde dehydrogenase (ADH1B and ALDH2) are important risks for esophageal squamous cell carcinoma in a Taiwanese population. In this study, we increased the sample size to investigate the modifying effect of lifetime alcohol consumption on the association between ADH1B and ALDH2 genotypes and the risks of esophageal cancer. A multicenter hospital-based case-control study was conducted between August 2000 and June 2004. Three hundred and thirty newly-diagnosed esophageal squamous cell carcinoma patients and 592 controls were recruited from National Taiwan University Hospital in Taipei and Kaohsiung Veterans General Hospital and Kaohsiung Medical University Hospital in Kaohsiung, Taiwan. Controls were matched to the case patients by gender and age within 4 years (case:control = 1:1-4). Polymorphisms of ADH1B and ALDH2 were genotyped by the method of PCR-RFLP. Individuals with ADH1B*1/*1 genotype had a 3.99-fold risk (95% CI = 2.13-7.48) of developing esophageal cancer, compared with those with ADH1B*2/*2 genotype, after adjusted for appropriate covariates. Individuals with ALDH2*1/*2 and ALDH2*2/*2 had 4.99-fold risk (95% CI = 3.11-7.99) and 4.24-fold risk (95% CI = 1.52-11.84), respectively, of developing esophageal cancer, compared with those with ALDH2*1/*1, after adjusted for appropriate covariates. We also found a modifying effect of lifetime alcoholic consumption on the association between genotypes of ADH1B and ALDH2 on esophageal cancer risk. These results suggest that ADH1B and ALDH2 polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed. (c) 2006 Wiley-Liss, Inc.