Ent-11 alpha-hydroxy-15-oxo-kaur-16-en-19-oic acid loaded onto fluorescent mesoporous silica nanoparticles for the location and therapy of nasopharyngeal carcinoma
Ent-11 alpha-hydroxy-15-oxo-kaur-16-en-19-oic acid loaded onto fluorescent mesoporous silica nanoparticles for the location and therapy of nasopharyngeal carcinoma
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Ent-11 α-羟基-15-oxo-kaur-16-en-19-oic酸负载到荧光介孔二氧化硅纳米颗粒上用于鼻咽癌的定位和治疗
作者：
Liu Yuke;Zhou Le;Tan Jing;Xu Weiqiang;Huang Guoliang;Ding Jie
Et-11α-羟基-15-氧代-Kaur-16-en-19-OIC酸(5F)是从中草药半边旗属植物半边旗中分离纯化的一种二萜类化合物，通过诱导癌细胞凋亡而对多种恶性肿瘤细胞具有抗肿瘤活性。然而，由于生理环境的复杂性和5F作为一种小分子抗癌药物的局限性，5F的体内抗肿瘤作用鲜有报道。在本研究中，我们利用FITC掺杂的纳米粒，通过增强渗透和滞留(EPR)效应，在鼻咽癌CNE2裸鼠移植瘤中积聚和传递5F。体内研究表明，纳米粒能有效地在CNE2移植瘤中传递5F，并且载药纳米粒能有效地抑制肿瘤的生长，且副作用最小。这项研究表明了将经过充分研究的纳米颗粒与传统草药治疗相结合的好处，并为5F化疗建立了一个传递平台。
Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (5F) is a diterpenoid that is isolated and purified from the Chinese herbal medicine Pteris semipinnata L., and is known to exert antitumour activity in several kinds of malignant cancer cells by leading cancer cells to apoptosis. However, the antitumour effect of 5F in vivo is rarely reported due to the complexity of the physiological environment and limitations of 5F as a small anticancer drug. In the present study, we utilized FITC-doped nanoparticles for the accumulation and delivery of 5F in nasopharyngeal carcinoma CNE2 tumours transplanted in nude mice by the enhanced permeation and retention (EPR) effect. In vivo studies demonstrated that nanoparticles could efficiently deliver 5F in CNE2 transplanted tumours, and the tumour growth was effectively inhibited by the drug-loaded nanoparticles with minimal side effects. The study indicated the benefits of combining well-studied nanoparticles with traditional herbal medicine treatment and establishes a delivery platform for 5F chemotherapy.