Metabolic control via the mitochondrial protein import machinery
Metabolic control via the mitochondrial protein import machinery
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DOI：
10.1016/j.ceb.2014.11.001
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发表时间：
2015-04-01
影响因子：
7.5
通讯作者：
Meisinger, Chris
中科院分区：
文献类型：
--
作者：
Opalinska, Magdalena;Meisinger, Chris
线粒体必须进口它们的大部分蛋白质来完成大量的代谢功能。复杂的输入机器介导细胞质中前蛋白的靶向和转运，并随后分选到它们的亚细胞器目的地。长期以来，人们一直认为这些机械的作用方式是静态的和本构主动的过程。然而，最近的研究表明，线粒体蛋白质进口机制受到强烈的调节机制，包括代谢物和代谢信号级联对蛋白质通量的直接控制。
Mitochondria have to import most of their proteins in order to fulfill a multitude of metabolic functions. Sophisticated import machineries mediate targeting and translocation of preproteins from the cytosol and subsequent sorting into their suborganellar destination. The mode of action of these machineries has been considered for long time as a static and constitutively active process. However, recent studies revealed that the mitochondrial protein import machinery is subject to intense regulatory mechanisms that include direct control of protein flux by metabolites and metabolic signalling cascades.