Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.
Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.
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发表时间：
1993-05
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通讯作者：
T. Collins
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作者：
T. Collins
参与动脉粥样硬化病变起始的几种内皮-白细胞粘附分子的基因含有内皮细胞中细胞因子诱导所需的功能性NF-κ B结合位点。该多效性转录因子家族的激活可以部分解释与内皮功能障碍相关的生长因子和细胞因子基因表达的多样性，以及在易损伤解剖部位观察到的内皮细胞复制增加。内皮氧化应激和NF-κ B家族转录因子的激活可能将与动脉粥样硬化病变起始相关的其他看似不同的危险因素联系到诱导内皮基因激活的最终共同途径中。
The genes for several endothelial-leukocyte adhesion molecules implicated in the initiation of the atherosclerotic lesion contain functional NF-kappa B binding sites which are required for cytokine induction in endothelial cells. Activation of this pleiotropic family of transcription factors may explain in part the diversity of growth factor and cytokine gene expression associated with dysfunctional endothelium, as well as the increased endothelial cell replication observed at lesion prone anatomic sites. Endothelial oxidant stress and activation of the NF-kappa B family of transcription factors may link the otherwise seemingly diverse risk factors associated with the initiation of the atherosclerotic lesion into a final common pathway for induced endothelial gene activation.