Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.
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DOI：
10.1161/circresaha.115.306885
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发表时间：
2016-05-27
影响因子：
20.1
通讯作者：
Walsh K
中科院分区：
文献类型：
--
作者：
Fuster JJ;Ouchi N;Gokce N;Walsh K
肥胖与心血管疾病的发展有因果关系。越来越多的证据表明，心血管疾病是肥胖导致的脂肪组织功能障碍的“附带损害”，它促进了机体内的慢性炎症状态。脂肪组织会分泌生物活性物质，称为脂肪因子，它们在很大程度上是炎症的调节器。脂肪组织的微环境会影响脂肪因子分泌体，对远端组织产生作用。肥胖通常会导致促炎性脂肪因子上调和抗炎性脂肪因子下调，从而导致心血管疾病的发病。在这篇综述中，我们着重于脂肪组织的微环境以及它如何通过脂肪因子的全身作用影响心血管疾病，包括动脉粥样硬化和缺血性心脏病。
Obesity is causally linked with the development of cardiovascular disorders. Accumulating evidence indicates that cardiovascular disease is the “collateral damage” of obesity-driven adipose tissue dysfunction that promotes a chronic inflammatory state within the organism. Adipose tissues secrete bioactive substances, referred to as adipokines, which largely function as modulators of inflammation. The microenvironment of adipose tissue will affect the adipokine secretome, having actions on remote tissues. Obesity typically leads to the upregulation of pro-inflammatory adipokines and the downregulation of anti-inflammatory adipokines, thereby contributing to the pathogenesis of cardiovascular diseases. In this review, we focus on the microenvironment of adipose tissue and how it influences cardiovascular disorders, including atherosclerosis and ischemic heart diseases, through the systemic actions of adipokines.