Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome
Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome
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DOI：
10.1073/pnas.0602025103
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发表时间：
2006-05-02
影响因子：
11.1
通讯作者：
Dunaif, A
中科院分区：
文献类型：
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作者：
Sam, S;Legro, RS;Dunaif, A
血脂异常是多囊卵巢综合征（PCOS）的一个特征，但其发病机制仍存在争议。我们对患有 PCOS 的女性的母亲进行了这项研究，以检验血脂异常是 PCOS 女性家庭遗传特征的假设，并调查年龄对生殖和代谢表型的影响。采集了 215 名 PCOS 女性非西班牙裔白人母亲和 62 名对照女性的空腹血。将代谢综合征的患病率与伊利诺伊州国家健康和营养检查调查中年龄相当的非西班牙裔白人女性的患病率进行比较。母亲的总胆固醇 (P < 0.001) 和低密度脂蛋白 (LDL) 胆固醇水平 (P = 0.007) 较高，而高密度脂蛋白和甘油三酯水平与对照女性相比没有差异。母亲 LDL 水平的唯一预测因素是女儿的 LDL 水平（r(2) = 0.11，P < 0.001）和她们自己的未结合睾酮水平（r(2) = 0.04，P = 0.03）。根据国家健康和营养检查调查 III，与肥胖的非西班牙裔白人女性相比，肥胖（体重指数 >= 30 kg/m(2)）母亲的代谢综合征患病率更高（P = 0.04）。百分之三十一的母亲有月经不规律的病史。这些母亲的雄激素水平、胰岛素抵抗标志物和低密度脂蛋白水平比月经规律的母亲更高。患有多囊卵巢综合症的女性的母亲的低密度脂蛋白水平会升高，这表明存在遗传性状。月经不规律的病史表明母亲具有多囊卵巢综合症的特征。肥胖母亲代谢综合征的患病率非常高。这些发现表明，多囊卵巢综合症患者的生殖和代谢异常随着年龄的增长而持续存在。
Dyslipidemia is a feature of polycystic ovary syndrome (PCOS), but its pathogenesis remains controversial. We performed this study of mothers of women with PCOS to test the hypothesis that dyslipidemia is a heritable trait in families of women with PCOS and to investigate the impact of age on reproductive and metabolic phenotypes. Fasting blood was obtained in 215 non-Hispanic white mothers of women with PCOS and 62 control women. The prevalence of metabolic syndrome was compared with that in non-Hispanic white women of comparable age from the National Health and Nutrition Examination Survey Ill. Mothers had higher total (P < 0.001) and low-density lipoprotein (LDL) cholesterol levels (P = 0.007), whereas high-density lipoprotein and triglyceride levels did not differ compared with control women. The only predictors of LDL levels in mothers were their daughters' LDL levels (r(2) = 0.11, P < 0.001) and their own unbound testosterone levels (r(2) = 0.04, P = 0.03). The prevalence of metabolic syndrome was increased in obese (body mass index >= 30 kg/m(2)) mothers compared with obese non-Hispanic white women from the National Health and Nutrition Examination Survey III (P = 0.04). Thirty-one percent of mothers reported a history of menstrual irregularity. These mothers had higher androgen levels, markers of insulin resistance, and LDL levels than mothers with regular menses. LDL levels are increased in mothers of women with PCOS, suggestive of a heritable trait. A history of menstrual irregularity identifies mothers with features of PCOS. Obese mothers have a very high prevalence of metabolic syndrome. These findings suggest that both the reproductive and metabolic abnormalities persist with age in PCOS.