Fabrication of chiral amino acid ionic liquid modified magnetic multifunctional nanospheres for centrifugal chiral chromatography separation of racemates.
Fabrication of chiral amino acid ionic liquid modified magnetic multifunctional nanospheres for centrifugal chiral chromatography separation of racemates.
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DOI：
10.1016/j.chroma.2015.04.045
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发表时间：
2015-06-26
期刊：
影响因子：
--
通讯作者：
Wei Y
中科院分区：
文献类型：
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作者：
Liu Y;Tian A;Wang X;Qi J;Wang F;Ma Y;Ito Y;Wei Y
随着纳米技术的飞速发展，特殊手性配体修饰的磁性纳米球在手性拆分方面显示出巨大的潜力。本研究设计了功能化手性离子液体修饰的磁性纳米球来分离手性氨基酸。这些修饰的磁性纳米球对5种外消旋氨基酸(D-和L-半胱氨酸、D-和L-精氨酸、D-和L-亮氨酸、D-和L-谷氨酰胺和D-和L-色氨酸)进行了直接手性分离。此外，利用安装在J型螺旋行星离心机上的螺旋管组件，建立了一种通过磁性纳米球实现对映体完全分离的新的在线方法。用该方法成功地拆分了手性化合物D-和L-色氨酸。这些结果表明，修饰后的纳米球具有良好的手性识别能力，可作为手性拆分多种外消旋体的潜在材料。
As the rapid development of nanotechnology, the magnetic nanospheres modified with special chiral selective ligands show a great potentiality in enantiomeric separation. In this study, magnetic nanospheres modified with task-specific chiral ionic liquid were designed for the separation of chiral amino acids. These modified magnetic nanospheres were effective in a direct chiral separation of five racemic amino acids (D- & L-cysteine, D- & L-arginine, D- & L-leucine, D- & L-glutamine and D- & L-tryptophan). Furthermore, a new online method for complete separation of the enantiomers via the magnetic nanospheres was established with centrifugal chiral chromatography using a spiral tube assembly mounted on a type-J coil planet centrifuge. One kind of chiral compounds, D- & L-tryptophan was resolved well using this method. These results demonstrated that the modified nanospheres display a good chiral recognition ability, and can be used as a potential material for chiral separation of various racemates.