Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients
Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients
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DOI：
10.1097/meg.0000000000001310
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发表时间：
2019-04-01
影响因子：
2.1
通讯作者：
Badawi, Rehab
中科院分区：
文献类型：
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作者：
Abd-Elsalam, Sherief;Arafa, Mona;Badawi, Rehab
背景 29-88% 的肝硬化患者会出现肌肉痉挛。它们对生活质量产生不利影响。本研究旨在评估美索巴莫作为控制肝硬化患者肌肉痉挛的新型疗法的有效性和安全性。 患者和方法 本研究对 100 名患有频繁肌肉痉挛（每周≥ 3 次痉挛）的慢性丙型肝炎患者和肝硬化患者进行了研究。这些患者中有一半接受美索巴莫治疗，另一半接受安慰剂治疗。这是通过均等随机化完成的。回答了有关肌肉痉挛的调查问卷。在治疗前、治疗1个月后和治疗结束后2周对患者的痉挛严重程度、持续时间和频率进行评估。分析肝、肾功能和电解质。此外，还检测到任何副作用。 结果 使用美索巴莫治疗的患者痉挛的频率和持续时间显着减少。此外，疼痛评分也显着改善。然而，安慰剂组没有观察到显着变化。美索巴莫的副作用很少，包括口干和嗜睡。 结论 美索巴莫似乎是一种有前途的安全且耐受性良好的药物，在治疗肝硬化患者的肌肉痉挛中发挥着作用。版权所有 (C) 2018 Wolters Kluwer Health, Inc. 保留所有权利。
Background Muscle cramps occur in 29-88% of patients with liver cirrhosis. They adversely affect quality of life. This study aimed to evaluate the efficacy and safety of methocarbamol as a novel therapy in controlling muscle cramps in cirrhotic patients.Patients and methods This study was carried on 100 patients with liver cirrhosis in addition to chronic hepatitis C who presented with frequent muscle cramps (>= three cramps per week). Half of these patients received methocarbamol and the other half received placebo. This was done through equal randomization. Questionnaires on muscle cramp were answered. Patients were evaluated before, after 1 month of treatment, and 2 weeks after washout of treatment in terms of severity, duration, and frequency of cramps. Liver, renal functions, and electrolytes were analyzed. Also, any side effect was detected.Results Patients who were treated with methocarbamol showed a significant decrease in the frequency and duration of cramps. Also, the pain score improved significantly. However, no significant changes were observed in the placebo group. Few side effects of methocarbamol were recorded, including dry mouth and drowsiness.Conclusion Methocarbamol seems to be a promising safe and well-tolerated medication, and plays a role in the treatment of muscle cramps in patients with liver cirrhosis. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.