Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population
Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population
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DOI：
10.1007/s00432-004-0634-z
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发表时间：
2005-04-01
影响因子：
3.6
通讯作者：
Katoh, T
中科院分区：
文献类型：
--
作者：
Komiya, Y;Tsukino, H;Katoh, T
目的：前列腺癌的发病率在低风险人群（如日本人）中呈上升趋势。这种增长的原因之一被认为与西方饮食有关，特别是红肉和脂肪的高摄入量。谷胱甘肽S-转移酶（GST）A1，T1，M1和P1是II相酶，对化学致癌物的活化和解毒很重要。研究方法：在这项研究中，190名日本男性前列腺癌患者和294名健康对照者，年龄频率匹配，比较了GSTA 1，GSTT 1，GSTM 1和GSTP 1基因型的频率。结果如下：在吸烟者中，前列腺癌患者中GSTA 1 *A/*B或 *B/*B基因型频率（27.8%）与对照组频率（18.2%;比值比[OR] = 1.72; 95%CI，1.01-2.94）相比显示出统计学显著性增加。吸烟者GSTT 1非缺失基因型与前列腺癌的发生相关（OR = 1.68; 95% CI，1.06-2.68）。以GSTA 1 *A/*A基因型和GSTT 1 null基因型为参照，GSTA 1 *A/*B或 *B/*B基因型和GSTT 1非缺失基因型的OR为2.08（95%CI为1.14-3.80）。另一方面，GSTM 1和GSTP 1 I105 V基因型之间没有显著的相关性。结论：这些发现表明GSTA 1和GSTT 1多态性与前列腺癌易感性相关，尤其是在吸烟者中。
Purpose: The incidence of prostate cancer is increasing in low-risk populations such as Japanese. One of the causes of this increase is considered to be associated with the Western diet, especially the high intake of red meat and fat. Glutathione S-transferase ( GST) A1, T1, M1, and P1 are phase II enzymes that are important for activation and detoxication of chemical carcinogens. Methods: In this study, 190 Japanese male patients with prostate cancer and 294 healthy controls, frequency-matched for age, were compared for frequencies of GSTA1, GSTT1, GSTM1, and GSTP1 genotypes. Results: Among smokers, the frequency of the GSTA1*A/*B or *B/*B genotype in patients with prostate cancer (27.8%) showed a statistically significant increase compared with the control group frequency (18.2%; odds ratio [OR] = 1.72; 95% CI, 1.01-2.94). In addition, the frequency of GSTT1 nondeletion genotype was associated with prostate cancer among smokers (OR = 1.68; 95% CI, 1.06-2.68). The OR of carrying the combined genotyping of GSTA1*A/*B or *B/*B and GSTT1 nondeletion was 2.08 (95% CI, 1.14-3.80) with the combined genotyping of GSTA1*A/*A and GSTT1 null as a reference. On the other hand, no significant associations were observed for genotypes of GSTM1 and GSTP1 I105V. Conclusions: These findings suggest that the GSTA1 and GSTT1 polymorphisms are associated with prostate cancer susceptibility, especially among smokers.