Ferritin conjugates as specific magnetic labels. Implications for cell separation.
Ferritin conjugates as specific magnetic labels. Implications for cell separation.
复制标题
铁蛋白缀合物作为特定的磁性标记。
DOI：
10.1016/s0006-3495(84)84271-x
复制
发表时间：
1984
影响因子：
3.4
通讯作者：
S. H. Young
中科院分区：
文献类型：
--
作者：
L. Odette;M. McCloskey;S. H. Young
Concanavalin A coupled to the naturally occurring iron storage protein ferritin is used to label rat erythrocytes and increase the cells' magnetic susceptibility. Labeled cells are introduced into a chamber containing spherical iron particles and the chamber is placed in a uniform 5.2 kG (gauss) magnetic field. The trajectory of cells in the inhomogeneous magnetic field around the iron particles and the polar distributions of cells bound to the iron particles compare well with the theoretical predictions for high gradient magnetic systems. On the basis of these findings we suggest that ferritin conjugated ligands can be used for selective magnetic separation of labeled cells.
