Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae.
Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae.
复制标题
内源合成的泰乐菌素在弗拉迪链霉菌中诱导 ermSF 中的重要作用。
DOI：
10.1128/aac.41.5.1203
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Weisblum,B
中科院分区：
文献类型：
--
作者：
Memili,E;Weisblum,B
We compared ermSF induction in wild-type Streptomyces fradiae NRRL B-2702 and that in GS-14, a tylA mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays an obligatory role in ermSF induction and (ii) tylosin, or a biosynthetic intermediate beyond tylactone, has an "autocrine" function that induces ErmSF synthesis, thereby enabling S. fradiae to resist higher levels of tylosin.
