Exogenously Triggered Nanozyme for Real-Time Magnetic Resonance Imaging-Guided Synergistic Cascade Tumor Therapy
Exogenously Triggered Nanozyme for Real-Time Magnetic Resonance Imaging-Guided Synergistic Cascade Tumor Therapy
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外源触发纳米酶用于实时磁共振成像引导的协同级联肿瘤治疗
DOI：
10.1021/acsami.2c07375
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发表时间：
2022
影响因子：
9.5
通讯作者：
Hui Wang
中科院分区：
文献类型：
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作者：
Hongji Liu;Junjun Wang;Chao Song;Ke Zhou;Biao Yu;Jialiang Jiang;Junchao Qian;Xin Zhang;Hui Wang
不受控制的治疗过程和细胞内高浓度的谷胱甘肽影响了化学动力学治疗（CDT）的疗效。在这里，嵌入N掺杂碳纳米片（IONCN）的氧化铁纳米晶体被设计为近红外光触发的纳米酶，用于协同级联肿瘤治疗。IONCN可以吸收980 nm的光并将其转化为局部热，这诱导氧化铁溶解，以在弱酸环境中产生Fe 2 +/Fe 3+，除了热消融癌细胞之外。形成的Fe 2+占据了芬顿反应的活性位点。形成的Fe 3+作为谷胱甘肽过氧化物酶放大氧化应激，提高抗肿瘤性能。IONCN可用于通过磁共振成像直观地跟踪治疗过程。这样的IONCN显示出作为外源性触发的纳米酶的巨大潜力，其通过整合的级联反应用于成像引导的协同癌症治疗。
The uncontrolled treatment process and high concentration of intracellular glutathione compromise the therapeutic efficacies of chemodynamic therapy (CDT). Here, iron oxide nanocrystals embedded in N-doped carbon nanosheets (IONCNs) are designed as a near-infrared light-triggered nanozyme for synergistic cascade tumor therapy. The IONCNs can absorb and convert 980 nm light to local heat, which induces the dissolution of iron oxide for generating Fe2+/Fe3+ in a weak acid environment, apart from thermal ablation of cancer cells. The formed Fe2+ takes on the active site for the Fenton reaction. The formed Fe3+ acts as glutathione peroxidase to magnify oxidative stress, improving the antitumor performance. The IONCNs can be used to visually track the treatment process via magnetic resonance imaging. Such IONCNs demonstrate great potential as an exogenously triggered nanozyme via an integrated cascade reaction for imaging-guided synergistic cancer therapy.