Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression.
Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression.
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雌二醇调节大鼠的快感缺失和行为绝望，以及产后抑郁症高危女性亚群的负面影响。
DOI：
10.1016/j.physbeh.2013.06.009
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发表时间：
2013
影响因子：
2.9
通讯作者：
Johnson,AlanKim
中科院分区：
文献类型：
--
作者：
Schiller,CrystalEdler;O'Hara,MichaelW;Rubinow,DavidR;Johnson,AlanKim
为了解决文献中的不一致之处，我们通过一系列啮齿动物实验和一项前瞻性自然主义人类研究测试了产后抑郁症（PPD）的跨物种雌激素戒断模型。所有大鼠在实验前均切除卵巢。第一项大鼠实验在实验动物（n= 7）和仅溶剂对照动物（n = 7）中检查了低剂量和高剂量雌二醇给药和停药对外侧下丘脑自我刺激（一种快感缺乏的行为指数）的影响。第二项大鼠实验在单独的实验组（n= 8）和仅溶剂对照组（n= 8）中检查了高剂量雌二醇戒断对强迫游泳试验（行为绝望指数）期间活动和不动性的影响。在人类研究中，有PPD史的女性（n= 8）和没有PPD史的女性（n= 12）在妊娠晚期至产后10天期间每天完成情绪评级并收集唾液样本（以评估雌二醇水平）。产后一个月评估PPD的存在。在动物研究中，雌二醇戒断组的大鼠表现出比对照组明显更大的不动性和更少的游泳。与雌二醇给药相比，雌二醇戒断导致对电刺激（多种强度）的反应降低。在人类研究中，在有或没有PPD病史的女性中，雌二醇和负面情绪之间没有显着关联。然而，在产后一个月发生PPD的妇女中，每日雌二醇水平与负面情绪之间存在相关性。尽管存在重要的跨物种差异，但大鼠和人类研究都提供了雌二醇对围产期抑郁症状影响的证据。
In an effort to address inconsistencies in the literature, we tested a cross-species estrogen withdrawal model of postpartum depression (PPD) with a series of rodent experiments and a prospective, naturalistic human study. All rats were ovariectomized prior to experimentation. The first rat experiment examined the effects of low- and high-dose estradiol administration and withdrawal on lateral-hypothalamic self-stimulation, a behavioral index of anhedonia, in experimental (n= 7) and vehicle-only control animals (n= 7). The second rat experiment examined the effects of high-dose estradiol withdrawal on activity and immobility during the forced swim test, an index of behavioral despair, in a separate group of experimental (n= 8) and vehicle-only control animals (n= 8). In the human study, women with (n= 8) and without (n= 12) a history of PPD completed mood ratings and collected saliva samples (to assess estradiol levels) daily during the third trimester of pregnancy through 10 days postpartum. The presence of PPD was assessed at one month postpartum. In the animal studies, rats in the estradiol withdrawal group demonstrated significantly greater immobility and less swimming than controls. Estradiol withdrawal resulted in reduced responding for electrical stimulation (multiple intensities) relative to estradiol administration. In the human study, there was no significant association between estradiol and negative affect among women with or without a history of PPD. However, there was a correlation between daily estradiol levels and negative affect in the women with incident PPD at one month postpartum. Despite important cross-species differences, both the rat and human studies provided evidence of the effects of estradiol on perinatal depressive symptoms.