Ventilatory and Cardiovascular Responses to Sufentanil Infusion in Dogs Anesthetized with Isoflurane
Ventilatory and Cardiovascular Responses to Sufentanil Infusion in Dogs Anesthetized with Isoflurane
复制标题
异氟烷麻醉犬输注舒芬太尼的通气和心血管反应
DOI：
10.1097/00132586-199006000-00007
复制
发表时间：
1989
影响因子：
5.7
通讯作者：
D. Ward
中科院分区：
文献类型：
--
作者：
I. Abdul;D. Ward
在16只慢性气管插管的狗上，用1和0.5最低肺泡浓度（MAC）的异氟醚麻醉，观察了舒芬太尼输注前和输注中对低氧、高氧和高碳酸的通气和血流动力学反应。舒芬太尼的输注速率可使每种异氟烷水平的呼气末二氧化碳（PETCO2）恒定为1.50 mmHg。在输注舒芬太尼之前，通过向吸入气体中加入CO2将PETCO2增加至50 mm Hg，以便在等二氧化碳条件下进行比较。舒芬太尼只引起轻微的血流动力学变化，但显着减少通气在两个水平的异氟烷。对高碳酸血症的通气反应显著降低，但对低氧的通气反应无显著变化。在输注舒芬太尼后，高氧引起了更大的每分钟通气量下降，并导致4只犬呼吸暂停。这些结果表明，在异氟烷麻醉期间给予舒芬太尼会导致中枢化学反射对兴奋性驱动的贡献减少，因此，外周化学反射的贡献相对增加。
The Ventilatory and hemodynamic responses to hypoxia, hyperoxia, and hypercapnia before and during sufentanil infusion were studied in 16 chronically tracheostornized dogs anesthetized with two concentrations, 1 and 0.5 minimal alveolar concentration (MAC) of isoflurane. Sufentanil was infused at a rate to obtain a constant end-tidal carbon dioxide (PETCO2) of ∼50 mm Hg for each isoflurane level. Before the sufentanil infusion, the PETCO2 was increased to 50 mm Hg by adding CO2 to the inspired gas, to allow comparisons at isocapnic conditions. Sufentanil caused only minor hemodynamic changes but significantly reduced ventilation during both levels of isoflurane. The Ventilatory response to hypercapnia decreased substantially, but there were no significant alterations in the ventilatory response to hypoxia. After sufentanil infusion, hyperoxia caused a larger decrease in minute ventilation and caused apnea in four dogs. These results suggest that administering sufentanil during isoflurane anesthesia causes a reduction in the contribution of the central chemoreflexes to ventilatory drive and, consequently, a relative increase in the contribution from the peripheral chemoreflexes.