Minnelide reduces tumor burden in preclinical models of osteosarcoma.
Minnelide reduces tumor burden in preclinical models of osteosarcoma.
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DOI：
10.1016/j.canlet.2013.02.050
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发表时间：
2013-07-28
期刊：
影响因子：
9.7
通讯作者：
Subramanian, Subbaya
中科院分区：
文献类型：
--
作者：
Banerjee, Sulagna;Thayanithy, Venugopal;Sangwan, Veena;Mackenzie, Tiffany N.;Saluja, Ashok K.;Subramanian, Subbaya
Osteosarcoma is the most common bone cancer in children and adolescents with a five-year survival rate of about 70%. In this study, we have evaluated the preclinical therapeutic efficacy of the novel synthetic drug, Minnelide, a prodrug of triptolide on osteosarcoma. Triptolide was effective in significantly inducing apoptosis in all osteosarcoma cell lines tested but had no significant effect on the human osteoblast cells. Notably, Minnelide treatment significantly reduced tumor burden and lung metastasis in the orthotopic and lung colonization models. Triptolide/Minnelide effectively downregulated the levels of pro-survival proteins such as heat shock proteins, cMYC, survivin and targets NF-κB pathway.
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