Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant
Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant
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DOI：
10.1080/01902140802022518
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发表时间：
2008-06-01
影响因子：
1.7
通讯作者：
Moore, Bethany B.
中科院分区：
文献类型：
--
作者：
Hubbard, Leah L. N.;Ballinger, Megan N.;Moore, Bethany B.
作者比较了4种化疗调理方案和2种全身照射（TBI）方案对移植后供体骨髓肺泡巨噬细胞（AM）重建的效率。TBI方案在诱导供体骨髓AM重建方面更有效。然而，接受13 Gy分剂量TBI或双重化疗方案（25 mg/kg布素粉× 4天+环磷酰胺100 mg/kg × 2天）均显示供体骨髓中AM再生显著。此外，两种方案都导致与AM过度产生前列腺素E-2和I-2相关的肺宿主防御受损，以及骨髓移植后AM吞噬受损。
The authors compared efficiency of alveolar macrophage (AM) reconstitution from donor bone marrow Post transplant following 4 chemotherapy conditioning regimens and 2 total body irradiation (TBI) regimens. TBI regimens are more effective in inducing AM reconstitution from donor marrow. However mire conditioned with 13 Gy split-dose TBI or a dual-chemotherapy regimen (25 mg/kg busu fan x 4 days plus cyclophosphamide 100 mg/kg x 2 days) both demonstrate significant AM repopulation from donor marrow. Additionally, both protocols resulted in impaired pulmonary host defense associated with overproduction of prostaglandin E-2 and I-2 by AMs and impaired AM phagocylosis post bone marrow transplant.