Ceroid-lipofuscinosis in Border Collie dogs
Ceroid-lipofuscinosis in Border Collie dogs
复制标题
边境牧羊犬蜡质脂褐质沉着症
作者：
R. Taylor;B. Farrow
总结五个边境牧羊犬犬蜡样脂褐质沉积症发展为进行性神经系统疾病之间的18和22个月的年龄。这些狗有行为异常，步态和视觉缺陷，并逐渐痴呆。所有的狗都有共同的祖先。组织的光镜检查表明，在神经元、视网膜神经节细胞和一些内脏细胞的细胞质中广泛积累了颗粒状的苏丹黑染色的自体荧光物质。在超微结构检查中，观察到不同形态的包涵体。
SummaryFive Border Collie dogs with ceroid-lipofuscinosis developed progressive neurological disease between 18 and 22 months of age. These dogs had behavioural abnormalities, gait and visual deficits and became progressively demented. All dogs examined had common ancestors. Light microscopic examination of tissues demonstrated extensive accumulation of granular, sudan black-staining autofluorescent material in the cytoplasm of neurones, retinal ganglion cells and some visceral cells. At ultrastructural examination inclusions of variable morphology were observed.
通过重新编程视网膜色素上皮细胞产生视网膜神经元。
影响因子：
4.6
作者：
Wang,Shu-Zhen;Ma,Wenxin;Yan,Run-Tao;Mao,Weiming
通讯作者：
Mao,Weiming