Methylmercury exposure and mortality in southern Japan: a close look at causes of death.
Methylmercury exposure and mortality in southern Japan: a close look at causes of death.
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日本南部的甲基汞暴露和死亡率：仔细研究死亡原因。
DOI：
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发表时间：
1986
影响因子：
6.3
通讯作者：
E. Lee
中科院分区：
文献类型：
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作者：
H. Tamashiro;M. Arakaki;M. Futatsuka;E. Lee
本研究按死因分析了死亡模式，以调查在水俣市（日本熊本县）一个小区域接触甲基汞的影响，该区域水俣病患者浓度最高。标准化死亡率（SMR）是根据研究地区的死亡原因计算的，使用整个城市的特定年龄死亡率作为标准。在研究区域，肝癌和慢性肝病的SMR显著高于1，并且与登记的水俣病患者的死亡率模式一致。虽然脑出血的死亡率过高，但脑梗塞和其他脑血管疾病的死亡率在研究地区要低得多。肝脏相关疾病的多种危险因素和脑血管死亡模式的可能解释进行了讨论，建议进一步调查。
This study examines mortality patterns by cause of death to investigate the effect of exposure to methylmercury in a small area of Minamata City (Kumamoto Prefecture, Japan), which has the highest concentration of patients with Minamata disease. Standardised mortality ratios (SMRs) are computed by cause of death for the study area, using the age specific rates of the entire city as a standard. The SMRs for liver cancer and chronic liver disease in the study area are significantly higher than unity and are consistent with the mortality patterns of registered Minamata disease patients. While an excess mortality is observed for cerebral haemorrhage, mortality from cerebral infarction and other cerebrovascular diseases is considerably lower in the study area. The multiple risk factors of liver related diseases and a possible explanation for the cerebrovascular mortality patterns are discussed to suggest further investigation.